S-2-CHLOROPROPANOIC ACID METHYL ESTER
L(-)-2-Chloropropionate methyl ester
CAS: 73246-45-4
Molecular Formula: C4H7ClO2
S-2-CHLOROPROPANOIC ACID METHYL ESTER - Names and Identifiers
S-2-CHLOROPROPANOIC ACID METHYL ESTER - Physico-chemical Properties
| Molecular Formula | C4H7ClO2 |
| Molar Mass | 122.55 |
| Density | 1.143g/mLat 25°C(lit.) |
| Boling Point | 80-82°C110mm Hg(lit.) |
| Flash Point | 101°F |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| BRN | 1720589 |
| Storage Condition | -20°C |
| Refractive Index | n20/D 1.417(lit.) |
| Physical and Chemical Properties | Appearance: colorless, clear liquid chemical content: 99% MINMIN optical purity (S/(S + R)): ≥ 98.0% moisture content: 0.1% MAX single impurity: 0.5% MAX |
| Use | Pesticide product intermediates |
S-2-CHLOROPROPANOIC ACID METHYL ESTER - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R36 - Irritating to the eyes R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2933 3/PG 3 |
| WGK Germany | 1 |
| FLUKA BRAND F CODES | 19 |
| HS Code | 29159000 |
| Hazard Class | 3 |
| Packing Group | III |
S-2-CHLOROPROPANOIC ACID METHYL ESTER - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | (S)-(-)-2-chloropropionic acid methyl ester, also known as α-chloropropionic acid methyl ester, it is a product in which alpha-H of methyl propionate is substituted with chlorine. Colorless clear transparent liquid with ether-like odor. Its α-chloro and carbonyl activities are industrially used in the synthesis of pharmaceuticals, pesticides and fragrances. |
| Application | methyl (S)-(-)-2-chloropropionate is an important chiral intermediate of medicine and pesticide, it is an important raw material for the synthesis of aryloxypropionic acid herbicides, plant growth regulators and some fungicides. chiral raw materials |
| preparation | step 1, preparation of the villerier reagent: add 178.0g(0.6mol) to a 250ml four-mouth bottle bis (trichloromethyl) carbonate, ice water cooled to 0~5 deg C, and Dropwise add 62.7g(0.72mol) of anhydrous N,N-dimethylacetamide as a solvent, the temperature increased significantly, mechanical stirring 1~2H reaction to obtain colorless villerier reagent solution; The second step, synthesis of (S)-(-)-2-chloropropionic acid methyl ester: At 20~30 ℃, add a small amount of N,N-dimethylacetamide to the solution of the villerier reagent obtained in step 1 with a constant pressure dropping funnel to obtain a mixed solution, and add 44.6g(0 .. 43mol) Dropwise to the mixed solution. R-methyl lactate, with obvious reaction temperature rise and gas generation; After dropwise addition, the mixture was heated to 60 ° C. And stirred for 5h, and the product solution (S)-(-) was obtained by chlorination reaction.-2-chloropropanoic acid methyl ester solution, gas phase tracking reaction process, cooling after the reaction; The third step, the second step of the obtained (S)-(-)-2-chloropropanoic acid methyl ester solution water, desolvation, steaming Distillation gave the product methyl (S)-(-)-2-chloropropionate; 57.0g, yield 90%, optical purity 97%. |
Last Update：2024-04-09 21:01:54
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Product Name: S)-(-)-Methyl 2-chloropropionate Request for quotation
CAS: 73246-45-4
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Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
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CAS: 73246-45-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
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